丁凤 博士

丁凤

博士 副研究员
主要学习工作经历：
1988-1993年 清华大学生物科学与技术系, 获学士学位;
1993-1998年 美国匹兹堡大学生物科学系, HHMI , 获博士学位;
1998-2002年 美国匹兹堡大学，博士后；
2000-2002年 匹兹堡大学转基因小鼠实验中心，兼技术总管；
2002-2008年 美国斯坦福大学医学院遗传学系，博士后；
2009-2013年 厦门大学生命科学学院，副教授, 福建省转基因与基因剔除小鼠培育与研究共用技术服务平台副主任
2014.1-至今 浙江清华长三角研究院 生物医药研究所 副研究员
嘉兴雅康博医学检验所 主任
浙江清华长三角研究院-雅康博生物医药研发中心副主任

主要研究领域与方向
肿瘤的诊断和个体化治疗。

代表性论文：
Lin D1, Wang Q, Ran H, Liu K, Wang Y, Wang J, Liu Y, Chen R, Sun Y, Liu R#, Ding F#. Abnormal response to the anorexic effect of GHS-R inhibitors and exenatide in male Snord116 deletion mouse model for Prader-Willi syndrome Endocrinology 2014,155(7):2355-62
Hu X, Lu X, Liu R, Ai N, Cao Z, Li Y, Liu J, Liu K, Wang H, Zhou C, Wu S, Han A, Ding F#, Chen R#. Histone crosstalk between H3S10ph and H4K5ac/K8ac regulates Brd4 activation for inducible gene. J Bio Chem 289(33):23154-67
Wang H, Zhu X, Zhu Y, Liu J, Hu X, Wang Y, Peng S, Chen Y, Chen R, Ding F* and Liu R*. Protein kinase D3 (PKD3) is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-kB signaling pathway. Biomed Res Int 014:968027.
Lin H, Lin Q, Liu M, Lin Y, Wang X, Chen H, Xia Z, Lu B, Ding F, Wu Q, Wang HR. PKA/Smurf1 signaling-mediated stabilization of Nur77 is required for anticancer drug cisplatin-induced apoptosis. Oncogene. 2014, 27;33(13):1629-39
Ai N, Hu X, Ding F#, Yu B, Wang H, Lu X, Zhang K, Li Y, Han A, Lin W, Liu R, Chen R. Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation. Nucleic Acids Res. 2011, 39(22):9592-604
Ding F, Yin Z, and Wang H-R. Ubiquitination in Rho signaling Curr Top Med Chem. 2011, 11(23):2879-87
Wang H, Zhou N, Ding F, Li Z, Chen R, Han A, Liu R. An efficient approach for site-directed mutagenesis using central overlapping primers. Anal Biochem. 2011, 418(2):304-6.
Tian M, Bai C, Lin Q, Lin H, Liu M, Ding F, Wang HR. Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity. FEBS Lett. 2011, 585(14):2199-204.
Mohan K, Ding F, Chaillet JR. Distinct roles of DMAP1 in mouse development. Mol Cell Bio. 2011, 31(9):1861-9.
Ding F, Li HH, Li J, Myers RM, Francke U. Neonatal maternal deprivation response and developmental changes in gene expression revealed by hypothalamic gene expression profiling in mice. PLoS ONE. 2010, 5(2): e9402.
Li H-H, Roy M, Kuscuoglu U, Spencer CM, Halm B, Harrison KC, Bayle JH, Splendore A, Ding F, Meltzer LA, Wright E，, Paylor R， Deisseroth K, Francke U. Induced Chromosome Deletions Cause Hypersociability and Other Features of Williams-Beuren Syndrome in Mice. EMBO Mol Med. 2009, 1(1):50-65.
Ding F, Li HH, Zhang S, Solomon NM, Camper SA, Francke U. SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth retardation, motor learning deficiency, hyperphagia and elevated ghrelin levels in mouse model for Prader-Willi syndrome. PLoS ONE. 2008 Mar 5;3(3):e1709
Cirio MC, Ratnam S, Ding F, Reinhart B, Navara C, Chaillet JR. Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprinting. BMC Developmental Biology 2008, 8:9.
Ding F, Prints Y, Dhar MS, Johnson DK, Garnacho-Montero C, Nicholls RD, Francke U. Lack of Pwcr1/MBII-85 snoRNA is critical for neonatal lethality in Prader-Willi syndrome mouse models. Mamm Genome. 2005 Jun;16(6):424-31.
Ding F, Patel C, Ratnam S, McCarrey JR, Chaillet JR. Conservation of Dnmt1o cytosine methyltransferase in the marsupial Monodelphis domestica. Genesis. 2003 Aug;36(4):209-13.
Ding F, Chaillet JR. In vivo stabilization of the Dnmt1 (cytosine-5)-methyltransferase protein. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14861-6.
Ratnam S, Mertineit C, Ding F, Howell CY, Clarke HJ, Bestor TH, Chaillet JR, Trasler JM. Dynamics of Dnmt1 methyltransferase expression and intracellular localization during oogenesis and preimplantation development. Dev Biol. 2002, 245(2):304-14.
Howell CY, Bestor TH, Ding F, Latham KE, Mertineit C, Trasler JM, Chaillet JR. Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene. Cell. 2001 Mar 23;104(6):829-38.
Ding F and Grabowski PJ, Identification of a protein component of a mammalian tRNASec complex implicated in the decoding fo UGA as selenocysteine, RNA, 1999, 5, 1561-1569
Ding F, Hagan JP, Wang Z, and Grabowski PJ, Biochemical properties of a novel U2AF65 protein isoform generated by alternative RNA splicing, Biochemical and Biophysical Research Communications, 1996, 224, 675-683.
Gong Y, Ding F, Li F, and Zhao N, Phospholipase C induced membrane fusion, Acta Biophysica Sinica, 1996, 12, (1), 43-50.
荣誉与获奖情况：
2007.10 杰出研究报告奖 美洲华人遗传学会 Outstanding Presentation Award By the Association of Chinese Geneticists in America (ACGA)
2013.4 厦门大学福建电信奖 (科研与教学）（校级）
2013.12 厦门大学英语教学比赛 一等奖 （校级）
2014.3 福建省高等教育教学成果 特等奖（省级，集体）
2014.9 国家级教学成果 二等奖（国家级，集体）
2015.1 嘉兴市创新类领军人才 （市级）
联系方式：
Tel：+86-15314925697
E-mail: fding7@foxmail.com
通信地址：浙江省嘉兴市南湖区亚太路705号创新大厦20楼 邮编314006